Evaluating the Impact of Polycyclic Aromatic Hydrocarbons on Genetic Mutations in Aquatic Organisms Through the CarcinogenMetaNet Model

Abstract

Polycyclic Aromatic Hydrocarbons (PAHs), which include many known carcinogens, have been studied extensively in regards to their various effects on aquatic organisms. Environmental contaminants, especially PAHs, are worthy of study because of their immediate environmental effects, potential human health risks, and possible danger to humanity as a species if these chemical agents cause extensive risks for the biological system (for humans and nonhuman entities). The extent of genetic damage caused by PAHs in aquatic organisms depends on the translocation routes taken and the exposure timeframe. In this study, we disclosed and evaluated the extent of the genetic damage done by PAHs in aquatic organisms, researchers utilized the CarcinogenMetaNet model, developed for genetic alteration evaluation using cellular activities. The CarcinogenMetaNet model is a computer program using data gathered from many studies in genomics, toxicology, and the environment (e.g., genomic and transcriptome bioinformatics, human health, and risk assessment studies) to study cancer risk outcomes. Our evaluations provided evidence that PAHs produced higher mutation rates, especially in context of DNA repairs and genomic stability, and, PaHs truly seem to represent a real threat for aquatic organisms toward causing carcinogenic risk. Then we evaluate how the CarcinogenMetaNet environmental model must also be viewed in the context of long-term ecological and evolutionary impacts on aquatic populations, as this study suggests PAH contamination in aquatic habitats produced observable impacts to the integrity of lineages belonging to aquatic organisms