Predisposing Infection with Orthopneumovirus (Hopv) and Orthorubulavirus (Horuv) Causes Increase Susceptibility To Infections with Human Metapneumovirus (Hmpv ) Leading To High Severity of (Artis) in Infants

Abstract

Viruses are the important causes of acute respiratory tract infections (ARTIs) in infants . (hOPV, and  ( hORUV) that included respiratory syncytial viruses whom predisposing viruses for infected with hMPV  . Human metapneumovirus (hMPV) , human type 2 orthopneumoviruses  hOPV    and human orthopnjeumovirus hORUV are among  viruses that causes severe (ARTIs) in infants .In this study we aimed to determine the role of  (hOPV, hORUV)  in decrease of immunity and causes infected with    hMPV.That lead to severe (ARTIs).

In the current  study  we aimed to study the human type 2 orthopneumovirus (Hopv ) and human orthorubulavirus (Horuv) in increase susceptibility to infectants with human metapneumovirus (HMPV) that lead to high severity of (ARTIs) in children between (two months to thirteen months)of age .

Methodes :- we collected swabs from nasopharyngeal from (180) infants with age less than sex months , started  December 2024 to April 2025 taken the samples and diagnosis by  real time polymerase  chain  reactions (RT-PCR ) were used to determined for  present of human metapneumovirus (hMPV) , human type 2 orthopneumovirus  ((hOPV) include respiratory syncytial virus  RSV)  and human orthorubulavirus (hORUV), also taken the date for entry the hospital and after that taken the history for each patients and diagnosed if present of present three viruses during  first three days and after five days of entry the central teaching hospital of peadiatric , in Baghdad , also determine clinical feature by the chest x-ray .

Results :- A total  samples that collection from children (180) nasopharyngeal  swabs were screened for present of predisposing infection (hMPV) in infants infected with (hOPV) and ((hORUV) include ( respiratory syncytial virus )(RSV) , and the impact  with the (hOPV) and (hORUV), for increase severity of (ARTIs) , we observed that higher infection with (hOPV)( from male 54(51.42%) and female 29(38.66%) ),(hORUV) from male 24  (22.85%) and female17 (22.66%) ) , rather than (hMPV) in male  3(2.85%) and female  2 (2.77%) , during  the first three days  of enter the hospital   . While after five days of enter the hospital  observed increase severity of ARTIs and increase infected of patients with hMPV,who infected with (hOPV) and (hORUV), during the first week . In this study observed infectious infants,  86(47.8% ) in groups  coinfected (hMPV , hOPV),  also seen  28(15.6% ) in group patients coinfection with   (hORUV ,hMPV)  and 60 ( 33.4% )in group of infants infected with the three viruses ( hMPV , hOPV and hORUV ) , while 23(12.8% ) in group infected with hMPV only, non negative results detection in all infants