Evaluation Of The Anti-Inflammatory Activity Of 1,4-Disubstituted 1h-1,2,3-Triazole Derivatives In Experimental Models

Abstract

The anti-inflammatory activity of 1,4-disubstituted 1H-1,2,3-triazole derivatives was studied in the «formalin-induced edema», «carrageenan-induced edema», and «serotonin-induced aseptic arthritis» models. In these models, ketoprofen, used as a reference drug at a dose of 10.0 mg/kg, demonstrated anti-inflammatory activity of 73.4%, 75%, and 75.8%, respectively, while sodium diclofenac showed activity of 66.3%, 67.7%, and 70.3%. Among the studied compounds, substance 1 demonstrated anti-inflammatory activity at a dose of 50.0 mg/kg in the «formalin-induced edema» and «carrageenan-induced edema» models with an effect of 78%, while in the «serotonin-induced aseptic arthritis» model, at a dose of 150.0 mg/kg, it showed an effect of 79.8%. The experiment revealed that this compound has a significant impact on the dynamics of inflammatory and anti-inflammatory cytokines in the blood serum, surpassing the corresponding results of the reference drugs.