Hybrid simulation model to study impact of oxygen variability on cellular mechanisms after brain injury

Abstract

Background: Maintaining adequate oxygen supply is crucial for the proper functioning of the brain, as disruptions in oxygen homeostasis can lead to severe consequences in brain-damaged conditions.

Aims: This study investigates the dynamics of oxygen levels in cells affected by various forms of brain damage, estimating oxygen concentration and the corresponding damage to give overall view between oxygen concentration and brain damage.

Methods: The present paper is a hybrid technique connecting computational engineering and brain medicine. A complete simulation method describing the oxygen distribution in brain and damage occurred due to decreasing oxygen concentration. 

Results: The results of this study reveal complex and multifaceted alterations in oxygen homeostasis following brain damage, while initial hypoxic conditions are commonly observed, the data also suggest the subsequent development of localized regions of hyperoxia, potentially due to disruptions in the delicate balance of oxygen supply and demand. These findings shed light on the dynamic and heterogeneous nature of oxygen regulation in the injured brain, with important implications for the understanding of pathological mechanisms and the development of targeted therapeutic strategies.

Conclusion: The insights gained from this research contribute to the growing body of knowledge on the critical role of oxygen in brain function and provide valuable guidance for future investigations and clinical interventions aimed at mitigating the devastating consequences of brain damage.