Comparison of Quality of Life in Breast Cancer Patients with Ovarian Insufficiency After Anthracycline and Taxane-Based Chemotherapy at Dr. Soetomo General Hospital, Surabaya

Abstract

Background: A comparison of anthracycline- and taxane-based chemotherapy in relation to the incidence of ovarian insufficiency and its impact on patients' quality of life in women at Dr. Soetomo General Hospital, Surabaya. Objective: To assess the difference in quality of life among breast cancer patients with ovarian insufficiency who received anthracycline- and taxane-based chemotherapy. Methods: This retrospective cohort study was conducted involving breast cancer patients with ovarian insufficiency who received chemotherapy at Dr. Soetomo General Hospital. Data were collected using validated questionnaires. Statistical analysis using the Mann-Whitney U test to determine the effect of anthracycline and taxane-based chemotherapy on patients' quality of life. Results: It can be determined that there is a relationship between the type of chemotherapy for breast cancer patients and differences in quality of life. This is consistent with the study's P-value of < 0.05, which means it is statistically significant. In terms of mean differences, it was found that there is a lower QOL value in the taxane group; however, this is still heavily influenced by other variables that may not have been assessed in this study. Conclusion: Breast cancer patients with ovarian insufficiency who underwent anthracycline-based chemotherapy experienced significantly worse quality of life compared to those treated with taxane-based chemotherapy (p = 0.025).