A rise in the risk of lung cancer in Iraq due to miRNA-423 rs6505162 polymorphisms.

Abstract

Cancer disease types represent a significant public health challenge globally, with its prevalence on the rise. It is the most frequently diagnosed cancer among patient's cases in human worldwide. Objective: evaluated genotyping and allele frequency of miR-423 via tetra-arm-PCR and highlight the role polymorphism among case-control lung cancer (LC). Results: The miRNA-423 rs6505162 polymorphisms in lung cancer shown three genotypes; AA, AC, and CC were 20%, 36.6%, and 43.3% among patients. Increase in risk is associated with miRNA-423 rs6505162: CC genotype exhibited an odds ratio (OR) of 3.05 with a 95% confidence interval (CI) of 0.96-9.6 (p=0.05). The results indicated a correlation between microRNA-423 and rs6505162. The results indicated a correlation between microRNA-423 and rs6505162 A>C genetic variation and the susceptibility to LC among Iraq. The C allele was found to significantly elevate the risk allele C of LC was showed an OR of 1.5 with a 95% CI of 0.72-5.11 (p=0.2). In conclusion, According to our findings, patients in Iraq who have the microRNA-423 CC genotype and the C allele are more vulnerable and have advanced stages of LC. Additional research with larger sample sizes is required to validate these findings..