Thrombophilia in Pregnant Females with Recurrent Early Pregnancy Loss: A Systematic Review

Abstract

Recurrent pregnancy loss is a complex health challenge. It is estimated that around 5% of females could experience two or more consecutive miscarriages. The exact etiology of recurrent pregnancy loss remains questionable. In clinical practice, determine the role of Protein C and Protein S Levels in pregnant females with recurrent early pregnancy loss. From a public health perspective, even a low molecular weight heparin and progesterone in this high-risk group of women might be worthwhile. The initial screening using search strategy and keywords on PubMed, Medline, Cochrane database, and Google Scholar identified 792 articles. After the screening, 584 articles were excluded based on titles, repeated records, the different language used (other than English), unavailable full texts, etc. 208 abstract were examined and based on abstarct dissimillar containt 169 articles were excluded. 39 full articles were examined for enrollment in study and 29 articles were excluded based on dissimilarity study design, methodology and containt. So in present review article, 10 articles up-to-date articles were included. This review aimed to summarize and critically analyze assembled knowledge on the etiology, risk factors i.e. protein C and protein S levels and management approach to recurrent early pregnancy loss and also determine the role of Protein C and Protein S Levels in pregnant females with recurrent early pregnancy loss.