Modeling The Mechanisms of Carcinogen-Induced Dna Damage And Preventive Interventions in Aquatic Environments With The Aquacarcnet Model

Abstract

The sustainability of our food systems. Carcinogenic contaminants in aquatic habitats carry substantial risk for marine organisms and, consequently, humans via food webs. Persistent environmental pollutants, including industrial chemicals and by-products, damage the DNA of aquatic organisms and drive carcinogenesis with ramifications for biodiversity and ecosystem stability. The paper describes AquaCarcNet to model carcinogen-induced DNA damage processes in aquatic organisms mechanistically. AquaCarcNet incorporates numerous mechanisms such as DNA adduct formation, DNA repair, and mutation accrual with different potential environmental variables such as contaminants, pollutant concentration, and water chemistry. Simulations suggest an increasing amount of damage with dose-dependence and possible implied thresholds for exposure. Predictions showed unavoidable genetic harm following chronic exposure within a number of scenarios; because of that, the assessment of risk is impactful, valuable, and important. AquaCarcNet generated a broader understanding not only of outcomes for individuals but also for communities, along with potential points of intervention. Risk mitigation and prevention could happen by better management practices in recovery (e.g., contaminant removal) and reduced exposure for aquatic organisms. These modelling accomplishments improve our understanding of carcinogenesis in the aquatic realm and represent an improved opportunity for management of chemicals and environmental determinants by predictive modelling. These two additional purposes form considerable advances in understanding carcinogen-induced DNA damage, adverse effects on aquatic life, and of individual foods on the pathway through the food system using biological mechanisms, and potential loss of function if there is damage, frequency of occurrence, etc, relative to different exposures through AquaCarcNet.