Comparative Assessment of Pathogenic Bacteria in Urinary Tract Infections and Renal Stones: Occurrence, Risk Factors, Genomic Profiles, and Impact on Renal Function

Abstract

Background: Urinary tract infection (UTI) is one of the most recurrent causes of urolithiasis. Over the last 20 years, the prevalence of infected stone has changed significantly. Several studies have found the relationship between urinary stones and urinary tract infection.

Methods: This study was carried out in the department of urology, and bacteriology of Al nasrih Hospitals, for six months period  after ethical approval. A total of 150 patients who had UTI with urinary stones were included. After taking informed written consent, detailed clinical history and necessary investigations were carried out in each patient. Urinary stone was sent for chemical analysis. Data were collected in separated case-record form and analyzed by SPSS 24.

Results: The mean age ± SD of the entire population (150 patients) was 38.8±14.6, ranging from 13 years old to 68 years old 42 patients (65%) with UTI were male, and 33(44%) were female. On the other hand, among the renal stone population, males constituted 62%, while females made up 37.3%. Among all, 150 patients (35.3%) exhibited positive bacterial growth on culture media, wherein majority were gram negative bacteria (30.19%). E. coli was the most common bacteria followed by Klebsiella (22.64%), p. aeruginusa (16.98%) & s. aureus  (15.9%). Most commonly found urinary stone. However renal stone had mild impact on renal function

Conclusion:  urinary tract infections are strongly linked to urolithiasis, with Gram-negative bacteria, especially E. coli, being the main Bactria that cause urinary stones to become infected. This emphasizes the necessity of microbiological testing and focused antibiotic therapy in stone-forming patients with UTIs.