Mechanisms of Phagocyte Recognition of Apoptotic Cells: Implications for Vascular and Immune Homeostasis: A Review

Abstract

All phagocytic cells including (Neutrophils (PMN) and macrophages and monocytes) are the most important cellular components of the non-specific immune system. They have receptors for a variety of molecule, such as Fc for IgG, Fc for complement and certain bacterial components. Apoptotic cell removal from the tissues is thought to be dependent on their death by apoptosis, followed by their recognition and phagocytosis by macrophages. This paper will discuss the molecular and cellular aspects of phagocytosis of apoptotic cells.