Formulation And Evaluation Of Nanostructured Lipid Carrier (Nlc)-Based Transdermal Patch Of Diclofenac Sodium For Chronic Pain Management
Keywords:
Diclofenac sodium, Chronic pain, Nanostructured lipid carriers (NLC), Transdermal patch, Sustained drug release, Skin permeationAbstract
Goal: Chronic pain affects millions worldwide, often requiring long-term administration of NSAIDs like diclofenac sodium. Oral therapy is associated with gastrointestinal complications and fluctuating plasma levels.
Objective: To formulate a nanostructured lipid carrier (NLC)-based transdermal patch of diclofenac sodium to provide sustained drug release, enhanced skin permeation, and improved patient compliance.
Methodology: Diclofenac-loaded NLCs were prepared using the melt-emulsification and ultrasonication technique and subsequently incorporated into a polymeric transdermal patch matrix. Formulations were evaluated for particle size, zeta potential, drug loading, encapsulation efficiency, mechanical strength, in vitro drug release, ex vivo skin permeation, and stability.
Results: The optimized NLC patch showed uniform particle size, high encapsulation efficiency, controlled drug release over 24 hours, and superior permeation through excised rat skin. Mechanical evaluation confirmed suitable flexibility, tensile strength, and adhesion for transdermal application. Stability studies indicated no significant changes in physicochemical properties over the storage period.
Conclusion: The developed NLC-based transdermal patch of diclofenac sodium demonstrates potential as an effective, patient-friendly alternative for chronic pain management with reduced systemic side effects..
