Evaluation of Embryonic Toxicology Of Selenium Nanoparticles Incorporated Dental Varnish And Commercial Varnish - A Comparative Study

Abstract

Introduction:Dental varnishes play a crucial role in preventive dentistry by protecting tooth enamel and reducing the risk of caries. Recent advancements in nanotechnology have introduced selenium nanoparticles (SeNPs) for enhanced antimicrobial and antioxidant properties. Aim: This study aims to compare the embryonic toxicology of selenium nanoparticles incorporated into dental varnish with that of commercially available dental varnish. Materials and Methods: Wild-type zebrafish embryos which were fresh water habitat were exposed to various concentrations (5, 10, 20, 40, and 80 µg/mL) of SeNPs-incorporated dental varnish. Embryonic mortality, hatching rates, and developmental malformations were assessed at 24-hour intervals. Results: The study observed a dose-dependent increase in embryonic mortality, delayed hatching, and a higher percentage of developmental malformations at higher SeNP concentrations. The SeNP-incorporated dental varnish exhibited higher toxicity compared to the commercial varnish.Conclusion: Selenium nanoparticles offer significant potential in enhancing dental varnishes but pose considerable embryonic toxicity risks at higher concentrations. Future research should optimise SeNP concentrations to balance benefits and minimise toxicological risks.