In silico Evaluation of Natural chalcones as Aromatase and EGFR Tyrosine Kinase inhibitors to Combat Breast and Ovarian Cancers

Abstract

Chemically α, β unsaturated carbonyl compounds are known as Chalcones and these are naturally occurring antioxidant flavonoids present in plant kingdom. Owing to their antioxidant mechanism chalcones contribute several biological activities and serve as natural molecules to treat some diseases and ailments. In this study the author had made an effort to report the available natural chalcones and their botanical sources, prediction of possibility for synthesis and anticancer activity against breast and ovarian cancer by Insilco methods using aromatase and EGFR Tyrosine Kinase enzyme models. Insilco studies had divulged that chalcones are complying the molecular properties, drug likeliness assessment studies and binding affinities with the targeted proteins and chalcones can be considered as unique leads to develop neutraceuticals and novel anticancer agents to treat breast and ovarian cancers.