Evaluation of the Efficacy of Manjishtadi Kashaya in the Management of Post-Acne Hyperpigmentation

Abstract

Acne is a prevalent dermatological disorder, often complicated by post-inflammatory hyperpigmentation (PIH), particularly in individuals with darker skin phototypes. PIH results from inflammation-driven melanogenesis and trauma-related varna vaishamya (discoloration). From an Ayurvedic perspective, this condition resembles Vyanga and Shyavata, arising from vitiated Pitta and Rakta dosha along with Vata involvement, leading to Raktadushti and disturbed skin complexion.

Manjishtadi Kashaya, a classical Rakta-shodhaka formulation, contains Manjishta (Rubia cordifolia), Sariva (Hemidesmus indicus), Guduchi (Tinospora cordifolia), Triphala, and other Pitta-Rakta pacifying drugs. These herbs exhibit Varnya (complexion-enhancing), Shothahara (anti-inflammatory), Raktaprasadana (blood-purifying), and Tvachya (skin-beneficial) properties, aligning with the pathological basis of PIH.

This study evaluates the efficacy of Manjishtadi Kashaya in reducing PIH by addressing both systemic (dosha-dushti) and local pathological processes. Clinical parameters, pigmentation changes, and risk factors (skin type, gender, severity of acne, sunlight exposure, lesion trauma) were assessed. Preliminary findings suggest that Manjishtadi Kashaya may provide a safe, holistic therapeutic approach in PIH by balancing Pitta-Rakta dushti, mitigating inflammation, and restoring normal varna.