BEST Endovascular Versus Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST-CLI) Trial

Authors

  • Raghu Motaganahalli Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, Indiana University, Indianapolis, IN, US Author
  • Matthew Menard Division of Vascular Surgery, Department of Surgery, Brigham and Women’s Hospitals, Harvard Medical School, Boston, MA, US Author
  • Matt Koopman Division of Vascular Surgery, Department of Surgery, Portland VA Medical Center, Portland, OR, US Author
  • and Alik Farber Division of Vascular Surgery, Department of Surgery, Boston Medical Center, Boston, MA, US Author

Keywords:

Surgical revascularisation, endovascular revascularisation, peripheral artery disease, BEST-CLI trial, critical limb ischaemia, chronic limb-threatening ischaemia, amputation

Abstract

The Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia trial (BEST-CLI) is an international, prospective, multicentre, multidisciplinary and pragmatic, open-label, superiority-based, comparative-effectiveness randomised controlled trial designed to address the knowledge gap in choosing the appropriate therapy for the treatment of critical limb ischaemia (CLI). This study compares the effectiveness of the best available surgical treatment with the best available endovascular treatment in adults with CLI who are eligible for both treatment options. The study has completed its enrolment phase and patients included in the study are currently being followed up to 50 months. Results of the study promise to provide us with answers to several questions regarding treatment options for patients with CLI, more recently referred to as chronic limb-threatening ischaemia.

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Published

2020-06-30

Issue

Vol. 3 No. 1 (2020): Vascular & Endovascular Review

Section

Articles