Correlation of Hrct, Mmp-9, Molecular Rapid Test, Hba1c and Quality of Life In Patients With and Without Tb-Dm Sequel
Keywords:
Tuberculosis, Diabetes Melitus, HRCT, MMP-9, TCM, Sequelae, Quality of lifeAbstract
Tuberculosis (TB) is a chronic infectious disease that can cause permanent lung damage (sequelae). Diabetes Mellitus (DM) is a comorbidity that can worsen TB healing. Evaluation of sequelae through various examination approaches such as: HRCT, MMP-9, TCM, HbA1c and patient quality of life was carried out to understand the relationship between the degree of lung damage and related clinical factors. An analytical observational study with a cross-sectional approach was conducted on TB patients who had been declared cured (after 6 months of treatment) and quality of life assessment using the WHOQOL-BREF instrument. Correlation analysis was performed to determine the relationship between these parameters and the degree of lung sequelae assessed radiologically. Results: The most significant HRCT images were fibrosis in TB- DM: 26 (86.7%), TB without DM: 10 (33.3%), p: 0.00, then followed by opacity in TB-DM: 21 (70.0%), TB without DM: 11 (36.7%), p: 0.01. While cavities were only found in TB-DM: 12 (40.0%), TB without DM: 8 (26.7%), p: 0.02. MMP-9 in TB-DM patients: 171.33 ± 50.49 TB without DM: 63.90 ± 37.98, p: 0.00. TCM in TB-DM patients: 30 (100%), TB without DM: 17 (56.7%). HbA1c in TB-DM patients: 7.12 ± 0.94 TB without DM: 4.19 ± 0.71, p: 0.00. Quality of life (WHOQOL-BREF): Physical TB-DM patients: 48.30 ± 5.79, TB without DM: 81.50 ± 6.15, p: 0.00. Psychological of TB-DM patients: 45.15 ± 4.95 TB without DM: 80.90 ± 4.48, p: 0.00. Social of TB-DM patients: 45.63 ± 5.29, TB without DM: 79.60 ± 5.90, p: 0.00. Environment of TB-DM patients: 44.83 ± 4.78 TB without DM: 81.50 ± 6.37, p: 0.00. Quality of Life score of TB-DM patients:
183.90 ± 11.94 TB without DM: 317.83 ± 25.758, p: 0.00. The combination of HRCT, MMP-9, TCM, and HbA1c, can be used as a prognostic indicator to assess the degree of sequelae in TB-DM patients. Early and proper diagnosis can improve quality of life and reduce long-term complications.
