To Determine Correlations of HBA1c And Lipid Indices with Oxidative and Inflammatory Markers, Lung Function (FEV1, FEV1/FVC), and Functional Capacity (6-minute walk test) in COPD Patients: A Review

Abstract

Chronic obstructive pulmonary disease (COPD) involves not only airflow limitation but also systemic metabolic, oxidative, and inflammatory changes. This review evaluates associations of glycated hemoglobin (HbA1c) and lipid indices with oxidative stress, inflammation, lung function, and functional capacity. Elevated HbA1c reflects glycemic dysregulation that worsens oxidative and inflammatory pathways, while atherogenic lipid profiles correlate with oxidative injury, reduced antioxidant defenses, and lower spirometric values (FEV₁, FEV₁/FVC). Markers like malondialdehyde (MDA) and TBARS are elevated, whereas superoxide dismutase (SOD) is diminished. Functional capacity, assessed by the six-minute walk test, declines with these systemic processes, linking metabolism to COPD progression.