sFlt-1/PlGF and BUN/Albumin Ratios as Novel Prognostic Scores in Critically Ill Preeclampsia Patients in the ICU
Keywords:
Preeclampsia, sFlt-1/PlGF Ratio, BUN/Albumin Ratio, Prognostic Score, Maternal Mortality, Acute Kidney Injury, Pulmonary Edema, Biomarker.Abstract
Preeclampsia remains a major cause of maternal morbidity and mortality, especially when complicated with multi-organ dysfunction such as renal and pulmonary failure. This study analyzes the utility of the sFlt-1/PlGF and BUN/Albumin ratios as novel prognostic scores for critically ill preeclampsia patients in the ICU. A retrospective observational study of 47 preeclampsia cases was conducted, analyzing the association between these biomarkers and critical clinical outcomes (pulmonary edema, acute kidney injury, mortality, ICU length of stay). Both the sFlt-1/PlGF and BUN/Albumin ratios demonstrated high accuracy as predictors of organ dysfunction, with specific cutoffs and AUC values exceeding 0.7. Implementation of these ratios provides a simple laboratory-based approach for early identification of severe preeclampsia complications in the ICU
