Integrating Ayurgenomics and Yoga Chikitsa in Non-Specific Chronic Low Back Pain: A Case Series on Functional Disability and Stress

Abstract

Background: Non-specific chronic low back pain is a multifactorial condition shaped by biomechanical, psychological, and constitutional factors. Ayurgenomics, which integrates Ayurvedic prakriti classification with physiological profiling, may explain inter-individual variability in treatment response. Recently, a standardized Generic Yoga Therapy Protocol comprising 18 validated techniques has been developed for NCLBP through expert consensus.

Objective: To explore how individuals with different prakriti types respond to a uniform 6-week Yoga Therapy protocol using standardized Ayurgenomic profiling via AyuSoft.

Methods: Six adults with clinically diagnosed NCLBP and varied prakriti types were selected to reflect constitution-based diversity. Each underwent prakriti assessment using AyuSoft developed by Centre for Development of Advanced Computing (C-DAC) and was classified into pradhāna–anubandha types. All participants completed a 6-week, 40-minute validated Yoga Therapy protocol. Outcomes were measured pre- and post-intervention using the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and Perceived Stress Scale (PSS).

Results: All participants demonstrated clinically meaningful improvement in functional disability. Response patterns differed by prakriti:

Kapha-pradhāna individuals showed consistent improvements across physical and psychological domains.

Pitta-pradhāna individuals showed rapid pain relief but varied emotional recovery.

Vāta-pradhāna participants exhibited notable stress reduction with limited pain change.

Conclusion: The standardized 40-minute Yoga Therapy protocol yielded functional and psychological benefits across all six NCLBP cases. Observed variability in therapeutic response aligned systematically with Ayurgenomic profiles, supporting prakriti-based personalization in yoga-based rehabilitation.