Design, Optimization, and Evaluation of Resveratrol Based Nanostructured Lipid Carriers for Enhanced Antidiabetic Efficacy
Keywords:
Saw Palmetto, Beta-Sitosterol, Pygeum Africanum, Phytotherapy, Benign Prostatic Hyperplasia, BPH 2.Abstract
Aim: To design, optimize and evaluate Resveratrol-loaded Nanostructured Lipid Carriers (NLCs) for improved drug delivery, controlled release, and enhanced therapeutic efficacy in the treatment of diabetes mellitus.
Objective: To overcome the limitations of conventional antidiabetic therapies by formulating optimized Resveratrol-loaded NLCs and evaluating their physicochemical properties, drug loading, entrapment efficiency, particle morphology (TEM), and in vitro release profile.
Method: Resveratrol-loaded NLCs were prepared by the high-speed homogenization method using varying concentrations of solid lipids, liquid lipids, and surfactants. The formulations were characterized for particle size, zeta potential, drug loading, and entrapment efficiency. FTIR and DSC analyses were performed to assess drug–excipient compatibility, while TEM was used to study particle morphology. In vitro release studies were conducted to evaluate controlled drug release behavior.
Result: FTIR and DSC studies confirmed the absence of drug–excipient incompatibility. The optimized formulation (RF4) showed a particle size of 196.2 nm, drug content of 95.21%, and entrapment efficiency of 95.38%. TEM images revealed smooth, spherical nanoparticles. The in vitro release profile indicated controlled drug release, and stability studies confirmed excellent physical stability under accelerated conditions.
Conclusion: Resveratrol-loaded NLCs demonstrated controlled release, high stability, and superior drug encapsulation, indicating strong potential as an effective and stable nanocarrier system for the management of diabetes mellitus.
