Estimation Of MMP-2 And MMP-9 In Glioma And Its Correlation With Pathological Prognosticators

Abstract

Glial cells give rise to gliomas, a form of primary tumor of the central nervous system. A matrix Metalloproteinases (MMPs) are a group of secreted, zinc-dependent endopeptidases that play a role in tissue remodelling processes such as wound healing, embryo implantation, tumour invasion, metastasis and angiogenesis. MMPs are involved in angiogenesis, cell migration, and tissue morphogenesis, among other normal physiological activities. MMP-2 and MMP-9 levels in the blood were measured and correlated with other prognostic factors, such as menopausal state, age, and gender. The circulatory level of MMP-2 and MMP-9 were determined enzyme-link immunosorbent assay in a total of 48 Glioma patients and the same number of controls. Level of MMP-2 significantly elevated in controls than Glioma patients (p<0.001) while MMP-9 showed a non-significant elevation in controls than patients. The level of MMP-2 in the male of both categories was significant in Age ≤40 and age 40-60 and also the level of MMP-9 significant in age ≤40 than 40-60 and ≥60. Level of MMP-2 and MMP-9 was higher in premenopausal women than perimenopausal and, but it was not substantial. This very high and complex regulation of the expression of MMPs represents a host response to the tumor and neoplastic cell interaction with the tumor stromal component is fundamental to cancer invasion and metastasis.