Systematic Review of The Effect Of Preoperative Cardiac Biomarkers on The Duration of Ventilator Use in Post-Operative Cabg Patients

Abstract

Prolonged ventilator duration after coronary artery bypass grafting (CABG) surgery is a critical issue in intensive care units (ICUs) as it can increase the risk of complications, length of hospital stay, and mortality. Several studies have shown that preoperative cardiac biomarkers, such as NT-proBNP, troponin I/T, and C-reactive protein (CRP), have the potential to be important predictors of ventilator duration, but the results are mixed and have not been systematically integrated. This study aims to comprehensively evaluate the existing evidence regarding the effect of preoperative cardiac biomarkers on ventilator duration in post-CABG patients. This study used a Systematic Literature Review method with a search of articles in PubMed, Scopus, and Web of Science databases, and followed the PRISMA guidelines for study selection. The results showed that high preoperative levels of NT-proBNP, troponin I/T, and CRP were consistently associated with longer ventilator requirements. Furthermore, the integration of biomarkers with traditional clinical factors resulted in a more accurate prediction of ventilation duration compared with clinical factors alone. These findings underscore the importance of preoperative cardiac biomarkers as predictive tools to assist in more optimal planning of post-CABG patient management.