Impact Of Flavonoid-Based Hypolipidemic Agents On Lipid Profile And Atherosclerosis Development In Hypercholesterolemic Rabbits

Abstract

The purpose of this research was to examine modifications in the lipid profiles of experimental rabbits with experimentally induced hypercholesterolemia and to explore the connection between these lipid variations and the onset of atherosclerosis. The investigation focused on analyzing the blood levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in rabbits, highlighting their contribution to the pathophysiology of atherosclerosis. Rabbits with hypercholesterolemia demonstrated marked elevations in total cholesterol and triglyceride levels, accompanied by diminished HDL levels, factors that promote the formation of atherosclerotic lesions. The study established that flavonoid-rich formulations successfully restore lipid balance by suppressing atherogenic lipoprotein levels and enhancing HDL concentrations, thus offering potential applications in preventing and managing cardiovascular conditions.