Potential Protective Effects Of Arabica Coffee Beans And Peels In Improving The Biological Condition Of Hyperlipidemic Rats

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death globally, responsible for an estimated 19.8 million deaths in 2022. Coffee beans and their Peels offer beneficial properties due to bioactive compounds like antioxidants and fiber. Aim: Determine the effectiveness of coffee beans and coffee arabica peels in improving the biological condition of hyperlipidemic rats. Materials and methods: Twenty-four male Sprague-Dawley albino rats, aged 10 weeks, weighing 150±10g, were split into 4 groups: The experiment was carried out in two periods. In the first period (three weeks), the first group was fed as a control group and was fed a control diet, while the other groups were fed the hyperlipidemic diets. In the second period (6 weeks), one of the hyperlipidemic rats fed on hyperlipidemic diet (10% animal fat and 1%. cholesterol). While the other groups were fed on a hyperlipidemic diet supplemented with 5% coffee beans and 5% coffee peels ,while one group was given a regular diet to act as a control positive. The experiment concluded with a blood sample and biochemical examination of the excised organs. Results: The mean values of serum triglycerides decreased by 33.88% (G3) and 64.18% (G4). While values of AST decreased by 5.28% (G3) and 31.72% (G4) for rats fed hyperlipidemic diet supplemented with coffee beans and  peels  as compared with control (+) G2. The gain in body weight per day, there were no significant difference between rats fed hyperlipidemic diet group (G2) and hyperlipidemic diet coffee beans 5% (G3) and coffee peels 5% G4.Conclusion: These findings highlight the potential of coffee beans and coffee arabica peels as functional ingredients in managing obesity and hyperlipidemia, offering a natural and accessible approach to promoting cardiovascular health.