Amelioration of Alcohol-Induced Gastric Ulcer by Dietary Intervention with Green Algae(Chlorophyceae) in Experimental Rats

Abstract

Stomach ulcers (also called peptic or gastric ulcers) are sores in the stomach. They can be serious, but most people recover with treatment. Bioactive compounds from green algae can treat gastric ulcers by reducing oxidative stress and inflammation and enhancing gastric mucosal defense. Objective: Determine the effectiveness of different concentrations of green algae (Chlorophyceae) in alleviating the Symptoms of Alcohol-Induced   in  rats with stomach ulcers . Materials and methods: Thirty-five adult male rats were allocated into a negative control group (n=7 rat) and ulcer-induced groups (n=28 rat), which received a single oral dose of ethyl alcohol at a concentration of 10 ml/kg. The ulcer-induced groups were further categorized into four equal subgroups, each receiving distinct treatments: (50, 100 and  150) mg/kg of green algae(Chlorophyceae). Results: The  group treated with oral administration of (green algae) 150 mg/kg treatment exhibited intermediate effects, with volume (3.99 ml) and acidity levels between those of green algae 50 and 100 mg/kg . These fi ndings suggest that while (green algae) 50 mg/kg may exacerbate gastric acidity, both green algae 50 and 100 mg/kg can partially inhibit acid secretion and may have potential gastroprotective properties. Conclusion: Green algae (Chlorophyceae) can have a beneficial effect on gastric ulcer parameters by decreasing gastric volume and acidity (both total and titratable), and increasing gastric pH in rats. The effects are dose-dependent, with higher concentrations showing a more significant impact. This suggests potential therapeutic value for ulcer treatment, likely through a combination of gastroprotective and acid-reducing mechanisms. Further research is needed to determine the efficacy and safety of green algae in human subjects.