VOLUME 6, 2023
The Role of Targeted Infra-popliteal Endovascular Angioplasty to Treat Diabetic Foot Ulcers Using the Angiosome Model: A Systematic Review
VOLUME 8, 2025
Assessment of Carotid Artery Wall Shear Stress and Plaque Vulnerability Using 4D Flow MRI in Patients Undergoing Carotid Endarterectomy
Duke University, Durham, NC, USA
Abstract
Vulnerable atherosclerotic plaques in the carotid arteries can lead to ischemic stroke even when the artery is not very narrow. It is believed that WSS helps lead to the accumulation and deterioration of plaques. Now, the latest technology in 4D Flow MRI enables doctors to measure the flow of blood non-invasively and map WSS in the carotid artery. This study examines if there is a connection between different carotid artery WSS patterns and the vulnerability of plaque, as seen on CEA specimens. Preoperative 4D Flow MRI was done on patients before their CEA surgery to examine three-dimensional blood flow and determine WSS measures. Examination of removed plaques after surgery showed signs of vulnerability, such as thin fibrous caps, lipid-rich necrotic cores, and black spots from bleeding. Researchers examined the relationship between WSS patterns and histopathological features. It was found that plaques located in areas of weak and constantly varying WSS tended to show signs of being vulnerable. This evidence backs the idea that changes in blood flow can lead to unstable plaques. Regions with only one direction of WSS had more firm and steady plaque characteristics. 4D Flow MRI allows for better assessment and measurement of carotid artery function, which reveals information regarding plaque behavior aside from the narrowing. It is evident from the data that magnetic resonance imaging with 4D Flow is especially useful in risk assessment and decision-making for stroke patients. Including hemodynamic data in assessing the carotid artery may help develop personalized treatment plans for people with cerebrovascular.
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.