Vascular and Endovascular Review

VOLUME 6, 2023

The Role of Targeted Infra-popliteal Endovascular Angioplasty to Treat Diabetic Foot Ulcers Using the Angiosome Model: A Systematic Review

VOLUME 8, 2025

Assessment of Carotid Artery Wall Shear Stress and Plaque Vulnerability Using 4D Flow MRI in Patients Undergoing Carotid Endarterectomy

Emily R. Caldwell
Duke University, Durham, NC, USA

Abstract

Vulnerable atherosclerotic plaques in the carotid arteries can lead to ischemic stroke even when the artery is not very narrow. It is believed that WSS helps lead to the accumulation and deterioration of plaques. Now, the latest technology in 4D Flow MRI enables doctors to measure the flow of blood non-invasively and map WSS in the carotid artery. This study examines if there is a connection between different carotid artery WSS patterns and the vulnerability of plaque, as seen on CEA specimens. Preoperative 4D Flow MRI was done on patients before their CEA surgery to examine three-dimensional blood flow and determine WSS measures. Examination of removed plaques after surgery showed signs of vulnerability, such as thin fibrous caps, lipid-rich necrotic cores, and black spots from bleeding. Researchers examined the relationship between WSS patterns and histopathological features. It was found that plaques located in areas of weak and constantly varying WSS tended to show signs of being vulnerable. This evidence backs the idea that changes in blood flow can lead to unstable plaques. Regions with only one direction of WSS had more firm and steady plaque characteristics. 4D Flow MRI allows for better assessment and measurement of carotid artery function, which reveals information regarding plaque behavior aside from the narrowing. It is evident from the data that magnetic resonance imaging with 4D Flow is especially useful in risk assessment and decision-making for stroke patients. Including hemodynamic data in assessing the carotid artery may help develop personalized treatment plans for people with cerebrovascular.

Keywords : Carotid Artery Wall Shear Stress (CAWSS), Plaque Vulnerability (PV), 4D Flow MRI, Carotid Endarterectomy (CE).
Erin Saricilar
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.
Mark Yang
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.

Abstract

Atherosclerotic disease significantly impacts patients with type 2 diabetes, who often present with recalcitrant peripheral ulcers. The angiosome model of the foot presents an opportunity to perform direct angiosome-targeted endovascular interventions to maximise both wound healing and limb salvage. A systematic review was performed, with 17 studies included in the final review. Below-the-knee endovascular interventions present significant technical challenges, with technical success depending on the length of lesion being treated and the number of angiosomes that require treatment. Wound healing was significantly improved with direct angiosome-targeted angioplasty, as was limb salvage, with a significant increase in survival without major amputation. Indirect angioplasty, where the intervention is applied to collateral vessels to the angiosomes, yielded similar results to direct angiosome-targeted angioplasty. Applying the angiosome model of the foot in direct angiosome-targeted angioplasty improves outcomes for patients with recalcitrant diabetic foot ulcers in terms of primary wound healing, mean time for complete wound healing and major amputation-free survival.
Keywords : Diabetic foot ulcer, angiosome, angioplasty