Vascular and Endovascular Review

VOLUME 6, 2023

The Role of Targeted Infra-popliteal Endovascular Angioplasty to Treat Diabetic Foot Ulcers Using the Angiosome Model: A Systematic Review

VOLUME 8, 2025

Current Trends in Vascular Graft Innovation: Biocompatibility, Longevity, and Clinical Applications

Anneliese Krause
Institute of Theoretical Physics, University of Heidelberg, Germany

Abstract

Vascular grafts constitute an essential component in the treatment of vascular disorders and injuries, and new improvements have shifted the focus on the construction and performance of such devices. Vascular grafts incorporated in this review include bioengineered and tissue-engineered grafts, new advanced materials, drug-coated systems and smart technologies. Recent development and advancement areas like decellularized scaffolds, cell-seeded constructs, and 3D bioprinting improve biocompatibility and reconstruction of tissue. Electrospun nanofibers composite polymers and biodegradable scaffolds possess better mechanical characteristics and applicability. Drug-releasing vascular grafts and smart, responsive systems associated with biosensors help deliver site-specific therapy and continuously monitor graft function. Efforts to overcome issues related to small-diameter grafts and the shift toward developing patient-customized solutions are also emerging. These trends are backed by enhancements in regulations and the joining of efforts of professionals from different fields to bring these new graft technologies into the clinics. Introducing bio-, material and technoscientific advancements into vascular grafts, the method is gradually becoming progressively efficient, long-lasting, and personalized, a significant advancement in vascular disease therapy. These advanced techniques are detailed in this review, emphasizing their promising benefits for patients and recognizing the prospects that are prominent aspects of vascular surgeons.

Keywords : Trends (TT), Vascular Graft Innovation (VGI), Biocompatibility (BC), Longevity (LL), Clinical Applications (CA).
Erin Saricilar
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.
Mark Yang
Lecture in accounting. University of Basrah, College of Administration and Economics, Department of Accounting.

Abstract

Atherosclerotic disease significantly impacts patients with type 2 diabetes, who often present with recalcitrant peripheral ulcers. The angiosome model of the foot presents an opportunity to perform direct angiosome-targeted endovascular interventions to maximise both wound healing and limb salvage. A systematic review was performed, with 17 studies included in the final review. Below-the-knee endovascular interventions present significant technical challenges, with technical success depending on the length of lesion being treated and the number of angiosomes that require treatment. Wound healing was significantly improved with direct angiosome-targeted angioplasty, as was limb salvage, with a significant increase in survival without major amputation. Indirect angioplasty, where the intervention is applied to collateral vessels to the angiosomes, yielded similar results to direct angiosome-targeted angioplasty. Applying the angiosome model of the foot in direct angiosome-targeted angioplasty improves outcomes for patients with recalcitrant diabetic foot ulcers in terms of primary wound healing, mean time for complete wound healing and major amputation-free survival.
Keywords : Diabetic foot ulcer, angiosome, angioplasty